ABSTRACT
Objectives: this study is aimed at determining the seroprevalence and possible infectivity factors of human cytomegalovirus [HCMV] in children affected by type 1 diabetes mellitus [T1DM] in the Aseer Region of KSA
Methods: a total of 205 children diagnosed with T1 DM who routinely attended the Diabetic Centre [DC] of Aseer Central Hospital [ACH] in Abha KSA were randomly selected. Another control group of 51 nondiabetic children were also selected. Sera of both groups were tested for HCMV-specific IgG and IgM using an indirect enzyme linked immune-sorbent assay [ELISA]
Results: the recorded HCMV-IgG seroprevalence rates were found to be higher in both groups of children than the IgM responses, which were consistently low. There were no obvious differences between the two groups in terms of HCMV responses. No significant variations were observed between girls and boys in terms of the seroprevalence rates. The highest positive IgG prevalence rates to HCMV were observed among 11- to 15-year-old children, and the least positive rates were noted in children younger than 5 years of age. Children from Abha city and its vicinity showed relatively higher HCMVspecific IgG and IgM responses rates than children from other localities
Conclusions: despite the presence of high HCMV-IgG response rates among the studied group of children, this study could not identify the associated clinical manifestations. There is no correlation between T1 DM and virus infectivity, as this research could not find differences in serological responses to the virus between the diabetic and non-diabetic children
ABSTRACT
To determine the effectiveness of myringotomy and grommet insertion [MGI] in patients with otitis media and effusion [OME], who failed medical treatment. Mahayel Private Hospital, Aseer Region, Saudi Arabia. Retrospective study. Records of eighty-six children [50 boys and 36 girls], aged 1-12 years, who had MGI for chronic OME between January 2005 and December 2010 were reviewed. Patients' data included: presenting complaints, indications for MGI, ear examination, hearing threshold and tympanometry. The age ranged from 1 to 12 years, 62 [72.1%] were less than 6 years old. Hearing and academic performance improved after grommet insertion. The study revealed that OME occurred mostly in preschool age. Hearing loss was noticed in 64 [74.4%], impaired social interaction in 37 [43%], difficulty in learning in 15 [17.4%] and delayed speech in 11 [12.8%]. The leading presenting complaint is hearing loss. MGI is indicated if medical treatment failed. Hearing threshold improves significantly postoperatively